Kynurenine as an Intermediate in the Formation of Nicotinic Acid from Tryptophane by Neurospora.
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چکیده
منابع مشابه
The niacin-tryptophan relationship in the metabolism of Xanthomonas pruni.
The investigations of Starr (1) demonstrated that Xunthomonas pruni requires an exogenous source of nicotinic acid when grown on a medium containing vitamin-free, acid-hydrolyzed casein, methionine, or glutamic acid to provide an organic form of nitrogen. Preliminary work in this laboratory showed that tryptophan could replace nicotinic acid for growth in a similar medium. This was the first kn...
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In 1945, Krehl et al. (1) observed that tryptophan and nicotinic acid were mutually interchangeable, within limits, in supporting the growth of rats. Since that time considerable evidence has accumulated which demonstrates the biosynthesis of niacin from tryptophan in the rat and other animals. Studies with Neurospora and mammals have demonstrated that the pathway from tryptophan goes through k...
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Since the observation (1) that tryptophan and nicotinic acid are mutually interchangeable, within limits, in supporting the growth of rats, considerable evidence has accumulated which indicates that biosynthesis of nicotinic acid can proceed from tryptophan (2-5). Unequivocal evidence for this transformation was provided by the experiments of Heidelberger et al. (6) who fed labeled tryptophan @...
متن کاملPrecursors of nicotinic acid in Escherichia coli.
It has now been firmly established that mammals and Neurospora are able to convert tryptophan to nicotinic acid via a biosynthetic pathway which contains several well characterized intermediate compounds (2). However, evidence has been accumulating which indicates that in bacteria the biosynthesis of nicotinic acid is accomplished by a different pathway. Volcani and Snell (3) demonstrated that ...
متن کاملKynureninase from Neurospora: Purification
As part of a study of kynurenine metabolism in Neurospora crassa, the enzyme, kynureninase, has been investigated. Evidence from studies with mycelial pads suggests that tryptophan gives rise to kynurenine, which may be degraded to anthranilic acid (1). Kynurenine is also oxidized to hydroxykynurenine, which is converted to hydroxyanthranilic acid (2). The similarity of these reactions, i.e. th...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 33 6 شماره
صفحات -
تاریخ انتشار 1947